刘北忠
2024-08-15 系统
个人信息
姓名：刘北忠
性别：男
职称：教授（博导）
职务：副院长
联系信息
邮箱：lbz2753@qq.com
地址：重庆市永川区萱花路439号
教育经历
1996.09-2001.07：重庆医科大学，临床检验诊断学，博士
1988.09-1993.07：重庆医科大学，医学检验，学士
工作经历
1993.07-1998.11，重庆医科大学医学检验系，助教
1998.11-2003.09，重庆医科大学医学检验系，讲师
2003.09-2008.07，重庆医科大学医学检验系，副教授
2008.07-2009.09，重庆医科大学医学检验系，教授
2009.09至今，重庆医科大学附属永川医院，教授
研究方向
作为负责人主持并完成了国家级、省部级等科研与教改课题30余项，作为主研参与完成了国家级、省部级等科研与教改课题18项；在国内外核心刊物上发表论文200余篇，其中SCI论文80余篇；作为副主编与编委，撰写并正式出版了全国规划教材与学术专著13部，全国规划CAI课件3部；获国家、省部等各级教学成果奖与科技成果奖20余项；已公开或授权国家发明专利15项，实用新型专利5项。目前主要开展白血病诊疗靶点的筛选与研究工作。
荣誉及奖项
1. 全国霍英东青年教师奖提名（2004）
2. 重庆市高等学校第2批优秀中青年骨干教师资助计划（2005）
3. 重庆医科大学首届优秀教师（2007）
4. 重庆市第二届学术技术带头人后备人选（2008）
5. 重庆医科大学优秀研究生导师（2011）
6. 重庆市永川区科学技术奖二等奖（2012）
7. 重庆市永川区第四届优秀科技论文一等奖（2013）
8. 重庆市永川区科技项目研发奖二等奖（2014）
9. 重庆市医学科技成果二等奖（2016）
10. 重庆医科大学优秀共产党员称号（2016）
11. 重庆市永川区第六届优秀科技论文一等奖（2017）
12. 重庆市永川区第三届十大优秀科技工作者（2017）
13. 重庆市医院协会医院管理先进工作者（2018）
14. 重庆市科技进步奖（2019）
15. 重庆医科大学优秀党务工作者（2021）
16. 重庆英才·创新创业领军人才（2021）
17. 重庆市永川区科技创新先进个人（2023）
发表论文
1. Meng Wang, Liang Zhong, Hongyan Zhang, Peng Wan, Xuan Chu, Xin Shao, Shuyu Chen, Ziwei Zhou, Lihua Yu, Beizhong Liu*. p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway. Medical Oncology. 2024 May 31;41(7):166.
2. Peng Wan, Liang Zhong, Lihua Yu, Chenlan Shen, Xin Shao, Shuyu Chen, Ziwei Zhou, Meng Wang, Hongyan Zhang, Beizhong Liu*. Lysosome-related genes predict acute myeloid leukemia prognosis and response to immunotherapy. Frontiers in Immunology. 2024 May 10:15:1384633.
3. Rui Xiao, Li Dong, Bo Xie**, Beizhong Liu*. A Mendelian randomization study: physical activities and chronic kidney disease. Renal Failure. 2024 Dec; 46(1): 2295011.
4. Chenlan Shen, Tong Wang, Ke Yang, Liang Zhong, Beizhong Liu*. Ultrasensitive detection of genetic variation based on dual signal amplification assisted by isothermal amplification and cobalt oxyhydroxide nanosheets/quantum dots. Microchimica Acta. 2024; 191: 12.
5. Ziwei Zhou, Liang Zhong, Xuan Chu, Peng Wan, Wenran Dan, Xin Shao, Shuyu Chen, Zhonghui Zhang, Yang Lu, Beizhong Liu*. HDAC11 mediates the ubiquitin-dependent degradation of p53 and inhibits the anti-leukemia effect of PD0166285. Medical Oncology. 2023; 40: 325.
6. Chenlan Shen, Liang Zhong, Peng Wan, Hengke Jia, Beizhong Liu*. Enzyme-free dual amplification biosensor based on functional nucleic acid and CDs/CoOOH for detection of leukemia fusion gene. Analytica Chimica Acta. 2023; 1276: 341623.
7. Xiao Wang, Liang Zhong, Wenran Dan, Xuan Chu, Xu Luo, Chen Liu, Peng Wan, Yang Lu, Zhenyan Liu, Zhonghui Zhang, Beizhong Liu*. MiR-454-3p promotes apoptosis and autophagy of AML cells by targeting ZEB2 and regulating AKT/mTOR pathway. Hematology. 2023; 28(1): 2223874.
8. Xin Shao, Liang Zhong, Xuan Chu, Peng Wan, Shuyu Chen, Ziwei Zhou, Hongyan Zhang, Meng Wang, Beizhong Liu*. ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia Proliferation Via the NF-κB Signaling Pathway. International Journal of Medical Sciences. 2023; 20(4): 520-529.
9. Shuyu Chen, Liang Zhong, Xuan Chu, Peng Wan, Zhenyan Liu, Yang Lu, Zhonghui Zhang, Xiao Wang, Ziwei Zhou, Xin Shao, Beizhong Liu*. Downregulation of Polo-Like Kinase 4 induces cell apoptosis and G2/M arrest in acute myeloid leukemia. Pathology Research and Practice. 2023; 243 : 154376.
10. Xuan Chu, Liang Zhong, Wenran Dan, Xiao Wang, Zhonghui Zhang, Zhenyan Liu, Yang Lu, Xin Shao, Ziwei Zhou, Shuyu Chen, Beizhong Liu*. DNMT3A R882H mutation promotes acute leukemic cell survival by regulating glycolysis through the NRF2/NQO1 axis. Cellular Signalling. 2023; 105: 110626.
11. Xuan Chu, Liang Zhong, Wenran Dan, Xiao Wang, Zhonghui Zhang, Zhenyan Liu, Yang Lu, Xin Shao, Ziwei Zhou, Shuyu Chen and Beizhong Liu*. DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway. Cell Communication and Signaling. 2022; 20: 168.
12. Zhenyan Liu, Liang Zhong, Wenran Dan, Xuan Chu, Chen Liu, Xu Luo, Zhonghui Zhang, Yang Lu, Peng Wan, Xiao Wang, Beizhong Liu*. miRNA-222-3p enhances the proliferation and suppresses the apoptosis of acute myeloid leukemia cells by targeting Axin2 and modulating the Wnt/β-catenin pathway. Biochemical and Biophysical Research Communications. 2022; 620: 83-91.
13. Xing Lin, Liang Zhong, Nian Wang, Xuan Chu, Beizhong Liu*. Hsa_circ_0103232 promotes melanoma cells proliferation and invasion via targeting miR-661/RAB3D. Cell Cycle. 2022; 21(17): 1811-1826.
14. Jie Hu#, Xiao-yu Wei#, Jin Xiang#, Pai Peng, Feng-li Xu, Kang Wu, Fei-yang Luo, Ai-shun Jin, Liang Fan, Bei-zhong Liu****, Kai Wang***, Ni Tang**, Ai-Long Huang*. Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera. Genes & Diseases, 2022; 9(5): 1290-1300.
15. Yang Lu, Liang Zhong, Xu Luo, Chen Liu, Wenran Dan, Xuan Chu, Peng Wan, Zhonghui Zhang, Xiao Wang, Zhenyan Liu, Beizhong Liu*. MiRNA-301b-3p induces proliferation and inhibits apoptosis in AML cells by targeting FOXF2 and regulating Wnt/β-catenin axis. Molecular and Cellular Probes. 2022; 63:101805.
16. Zhonghui Zhang, Liang Zhong, Wenran Dan, Xuan Chu, Chen Liu, Xu Luo, Peng Wan, Zhenyan Liu, Yang Lu, Xiao Wang, Beizhong Liu*. ZFP91 promotes cell proliferation and inhibits cell apoptosis in AML via inhibiting the proteasome-dependent degradation of RIP1. International Journal of Medical Sciences, 2022; 19(2):274-285.
17. Wenran Dan, Liang Zhong, Zhonghui Zhang, Peng Wan, Yang Lu, Xiao Wang, Zhenyan Liu, Xuan Chu, Beizhong Liu*. RIP1-dependent Apoptosis and Differentiation Regulated by Skp2 and Akt/GSK3β in Acute Myeloid Leukemia. International Journal of Medical Sciences, 2022; 19(3): 525-536.
18. Wenran Dan, Liang Zhong, Lihua Yu, Ling Xiong, Jian Li, Jiao Ye, Xu Luo, Chen Liu, Xuan Chu, Beizhong Liu*. Skp2 promotes APL progression through the stabilization of oncoprotein PML-RARα and the inhibition of JunB expression. Life Sciences, 2022; 289: 120231.
19. Chen Liu, Liang Zhong, Chenlan Shen, Xuan Chu, Xu Luo, Lihua Yu,Jiao Ye, Ling Xiong, Wenran Dan, Jian Li, Beizhong Liu*. CRNDE enhances the expression of MCM5 and proliferation in acute myeloid leukemia KG-1a cells by sponging miR-136-5p. Scientific Reports, 2021; 11: 16755.
20. Jie Hu#, Pai Peng#, Kai Wang#, Liang Fang, Fei-yang Luo, Ai-shun Jin, Beizhong Liu***, Ni Tang**, Ai-long Huang*. Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies. Cellular & Molecular Immunology, 2021; 18(4): 1061-1063.
21. Yinyin Xu, Jing Guo, Jing Liu, Ying Xie, Xin Li, Hongmei Jiang, Jingjing Wang, Ziyi Peng, Jingya Wang, Sheng Wang, Chao Wan, Lanting Chen, Yuping Zhong, Beizhong Liu*, Zhiqiang Liu*. Hypoxia-induced CREB cooperates MMSET to modify chromatin and promote DKK1 expression in multiple myeloma. Oncogene, 2021; 40(7):1231-1241.
22. JingyaWang, Yinyin Xu, Xiaoli Zhang, ShengWang, Ziyi Peng, Jing Guo, Hongmei Jiang, Jing Liu, Ying Xie, JingjingWang, Xin Li, Juan Liao, ChaoWan, Lihua Yu, Jinsong Hu***, Beizhong Liu**, Zhiqiang Liu*. Leptin correlates with monocytes activation and severe condition in COVID-19 patients. Journal of Leukocyte Biology. 2021; 1–12.
23. Chenlan Shen, Liang Zhong, Ling Xiong, Chen Liu, Lihua Yu, Xuan Chu, Xu Luo, Min Zhao**, Beizhong Liu*. A novel sandwich-like cytosensor based on aptamers-modified magnetic beads and carbon dots/cobalt oxyhydroxide nanosheets for circulating tumor cells detection. Sensors and actuators b-chemical, 2021; 331: 129399.
24. Xu Luo, Liang Zhong, Lihua Yu, Ling Xiong, Wenran Dan, Jian Li, Jiao Ye, Xuan Chu, Chen Liu, Beizhong Liu*. TRIB3 destabilizes tumor suppressor PPARα expression through ubiquitin-mediated proteasome degradation in acute myeloid leukemia. Life Sciences, 2020; 257: 118021.
25. Xuan Chu, Liang Zhong, Lihua Yu, Ling Xiong, Jian Li, Wenran Dan, Jiao Ye, Chen Liu, Xu Luo, Beizhong Liu*. GSK‑J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK‑J4 and decitabine in acute myeloid leukemia KG‑1a cells. Cancer Cell International, 2020; 20: 209.
26. Jian Li, Liang Zhong, Jiao Ye, Ling Xiong, Lihua Yu, Wenran Dan, Pengqiang Zhong, Zhen Yuan, Dongdong Liu, Juanjuan Yao, Junmei Liu, Beizhong Liu*. NLS-RARa blocks cell differentiation by inhibiting the retinoic acid signalling pathway. Biochemical and Biophysical Research Communications, 2020; 528(2): 276-284.
27. Chen J#, Zhang ZZ#, Chen YK#, Long QX#, Tian WG#, Deng HJ, Hu JL, Zhang XX, Pu-Liao, Xiang JL, Wang DX, Hu P, Zhou FC, Li ZJ, Xu HM, Cai XF, Wang DQ, Hu Y, Tang N, Liu BZ***, Wu GC**, Huang AL*. The clinical and immunological features of pediatric COVID-19 patients in China. Genes & Diseases. 2020 Dec;7(4): 535-541.
28. Long QX#, Liu BZ#, Deng HJ#, Wu GC#, Deng K#, Chen YK#, Liao P, Qiu JF, Lin Y, Cai XF, Wang DQ, Hu Y, Ren JH, Tang N, Xu YY, Yu LH, Mo Z, Gong F, Zhang XL, Tian WG, Hu L, Zhang XX, Xiang JL, Du HX, Liu HW, Lang CH, Luo XH, Wu SB, Cui XP, Zhou Z, Zhu MM, Wang J, Xue CJ, Li XF, Wang L, Li ZJ, Wang K, Niu CC, Yang QJ, Tang XJ, Zhang Y, Liu XM, Li JJ, Zhang DC, Zhang F, Liu P, Yuan J, Li Q, Hu JL*, Chen J*, Huang AL*. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nature Medicine. 2020 Jun;26(6):845-848.
主持项目
1. 国家自然科学基金委青年基金项目，NSFC30300449，中药苦参作用靶点的活细胞内筛选与研究，2004/01-2006/12，21万，已完成，主持
2. 国家中医药管理局项目，No.02-03ZP52，苦参碱作用靶点的酵母三杂交系统研究，2003/03-2005/03，5万元，已完成，主持
3. 重庆市科委项目，No.2002-1898，白血病新基因的结构与功能研究，2003/01-2005/12，4万元，已完成，主持
4. 重庆市自然科学基金计划重点项目，CSTC2011BA5037，NE介导APL发生的诊疗新靶点与方法研究，2011/06-2014/06，20万元，已完成，主持
5. 永川区科委创新能力建设项目，YCSTC2011BF5001，永川医学实验中心科技资源平台建设及对永川“秀芽”药用价值开发示范研究，2011/08-2014/08，，5万元，已完成，主持
6. 国家自然科学基金委面上项目，NSFC81171658，APL诊疗新靶点的筛选与研究，2012/.01-2015/12，58万，已完成，主持
7. 国家863计划子项目，No. 2011AA02A111-FB，2型糖尿病合并代谢综合征患者空腹血浆游离脂肪酸的变化，2012/09-2017/09，10万元，已完成，主持
8. 国家自然科学基金委面上项目，NSFC81772280，NLS-RARα作为APL早期诊断标志物的研究，2018/01-2021/12，56万，已完成，主持
9. 重庆市科技局重庆英才计划项目，cstc2022ycjh-bgzxm0034，NE介导CUX1致APL发生发展的机制研究，2022/01-2024/12，40万，在研，主持
